As a result of donation after circulatory death liver graftsââ?¬â?¢ poor tolerance to cold storage, there has been increasing research interest\nin normothermic machine perfusion. This study aims to systematically review the current literature comparing normothermic\nperfusion to cold storage in donation after circulatory death liver grafts and complete a meta-analysis of published large animal\nand human studies. A total of nine porcine studies comparing cold storage to normothermic machine perfusion for donation after\ncirculatory death grafts were included for analysis. There was a significant reduction in AST (mean difference âË?â??2291 U/L, CI (âË?â??3019,\nâË?â??1563); P ââ?°Â¤ 0.00001) and ALT (mean difference âË?â??175U/L, CI (âË?â??266, âË?â??85);
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